PT-141 (Bremelanotide)

PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide with the sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH. This structure is a synthetic analog of the naturally occurring α-melanocyte-stimulating hormone (α-MSH), a neurohormone involved in various physiological processes. The cyclized structure and D-phenylalanine substitution contribute to its enhanced stability and receptor binding profile compared to linear α-MSH. Research into melanocortin peptides, including PT-141, began with the discovery of α-MSH and its diverse biological roles. PT-141 was developed through modifications of the α-MSH sequence, specifically focusing on its melanocortin receptor affinity. Early studies aimed to understand the structure-activity relationships of melanocortin peptides and their interactions with different melanocortin receptor subtypes. PT-141 acts as an agonist at melanocortin receptor subtypes MC3R and MC4R. These receptors are expressed in various tissues, including the central nervous system. In research, PT-141 has been utilized to investigate the functional roles of these receptors in different biological pathways. Its specific binding profile allows for targeted studies on melanocortin system modulation in controlled laboratory environments. This peptide is strictly for use in laboratory research and academic investigations. It is employed to explore the mechanisms of melanocortin receptor activation and the downstream cellular and physiological effects in various experimental models.